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Table 2 Characteristics (authors, study design and subject, geometry and location of implant placement, study groups, follow-up period and outcomes) of studies and case reports with human subjects included in the present systematic review

From: Does vitamin D have an effect on osseointegration of dental implants? A systematic review

Authors Study design Study subjects Number of implans, n Implant Dimension Ø × L in mm Implant Location Study groups, n = subjects Follow-up Outcome
Flanagan et al. [37] Case report 1 Man 18 Implants N/A Mandible & maxilla Patient with ESRD VD3 supplementation, phosphate binders and calcium cinacalcet calcimimeti, 3 × dialysis/week 7 months Successful immediate implantation after extraction
Bryce et al. [38] Case report 1 Man 1 Ti Implant 4.3 × 10 Mandible Patient with serve vitamin D deficiency (25 OH vitamin D < 10 nmol/L) 5 months Failed immediate implantation after extraction due to missing osseointegration
Fretwurst et al. [39] Case report 2 Men 9 TiZr Implants 4.1 × 12–4.3 × 7 Mandible Healthy patients with vitamin D deficiency ND Implant placement failed once/twice, after VD3 supp. implant placement was successful
Guido Mangano et al. [36] Human retrospective study 885 Humans 1740 implants N/A Mandible and maxilla Group-1 (n = 48): < 10 ng/mL 25 (OH)
Group-2 (n = 448): 10–30 ng/mL 25 (OH)
Group-3 (n = 410): > 30 ng/mL 25 (OH)
4 months Tendency to more EDIF the lower the 25 (OH) vitamin d level Group-1: 11,1% EDIF; Group-2 4,4% EDIF; Group-3: 2,9%
Kwiatek et al. [35] Human prospective study 122 Humans 122 Ti implants 3,3–4,2 × 8–11,5 Mandible Group-1: (n = 43): < 30 ng/ml 25 (OH)
Group-2: (n = 48): D < 30 ng/ml 25 (OH) + supp of VD3
Group-3 (n = 31): > 30 ng/ml 25 (OH)
6 and 12 weeks Group-2 had significant higher bone level changes around dental implants compared to Group-1, after 12 weeks
  1. VD3:1,25(OH)2 D3; 25 (OH): 25 (OH) Hydroxyvitamin D; Supp.:Supplementation; EDIF: Early dental implant failure; ESRD: end-stage renal disease, N/A: not available