Table 2 Characteristics (authors, study design and subject, geometry and location of implant placement, study groups, follow-up period and outcomes) of studies and case reports with human subjects included in the present systematic review
From: Does vitamin D have an effect on osseointegration of dental implants? A systematic review
Authors | Study design | Study subjects | Number of implans, n | Implant Dimension Ø × L in mm | Implant Location | Study groups, n = subjects | Follow-up | Outcome |
|---|---|---|---|---|---|---|---|---|
Flanagan et al. [37] | Case report | 1 Man | 18 Implants | N/A | Mandible & maxilla | Patient with ESRD VD3 supplementation, phosphate binders and calcium cinacalcet calcimimeti, 3 × dialysis/week | 7 months | Successful immediate implantation after extraction |
Bryce et al. [38] | Case report | 1 Man | 1 Ti Implant | 4.3 × 10 | Mandible | Patient with serve vitamin D deficiency (25 OH vitamin D < 10 nmol/L) | 5 months | Failed immediate implantation after extraction due to missing osseointegration |
Fretwurst et al. [39] | Case report | 2 Men | 9 TiZr Implants | 4.1 × 12–4.3 × 7 | Mandible | Healthy patients with vitamin D deficiency | ND | Implant placement failed once/twice, after VD3 supp. implant placement was successful |
Guido Mangano et al. [36] | Human retrospective study | 885 Humans | 1740 implants | N/A | Mandible and maxilla | Group-1 (n = 48): < 10 ng/mL 25 (OH) Group-2 (n = 448): 10–30 ng/mL 25 (OH) Group-3 (n = 410): > 30 ng/mL 25 (OH) | 4 months | Tendency to more EDIF the lower the 25 (OH) vitamin d level Group-1: 11,1% EDIF; Group-2 4,4% EDIF; Group-3: 2,9% |
Kwiatek et al. [35] | Human prospective study | 122 Humans | 122 Ti implants | 3,3–4,2 × 8–11,5 | Mandible | Group-1: (n = 43): < 30 ng/ml 25 (OH) Group-2: (n = 48): D < 30 ng/ml 25 (OH) + supp of VD3 Group-3 (n = 31): > 30 ng/ml 25 (OH) | 6 and 12 weeks | Group-2 had significant higher bone level changes around dental implants compared to Group-1, after 12 weeks |