Table 2 PolyP-driven thrombin generation of functionalized silk fibroin membranes
From: Polyphosphate-loaded silk fibroin membrane as hemostatic agent in oral surgery: a pilot study
Plasma with buffer (PPP) | Silk control | µg/mm2 silk + polyP | |||||||
|---|---|---|---|---|---|---|---|---|---|
2 | 6 | 20 | 60 | 200 | 600 | 2000 | |||
ETP (nM⋅min) | 519.2 ± 413 | 955.5 ± 119 | 970.6 ± 170 | 1098 ± 310 | 1279.9 ± 183 | 1391.2 ± 160 | 1525.7 ± 227 | 1339.3 ± 9 | −1 |
Peak thrombin (nM) | 52.3 ± 50 | 198.4 ± 70 | 175.9 ± 53 | 207.8 ± 119 | 246.2 ± 51 | 267.3 ± 38 | 310.1 ± 27 | 243.4 ± 56 | −1 |
Time to peak (min) | 28.8 ± 7 | 15.3 ± 1.4 | 17.1 ± 5 | 13.1 ± 6 | 11.8 ± 1.8 | 10.2 ± 0.5 | 9.8 ± 0.7 | 8.9 ± 0.6 | −1 |
Lag time (min) | 23.3 ± 6 | 12.8 ± 0.7 | 14 ± 4 | 10 ± 4 | 9.1 ± 1.5 | 7.4 ± 0.1 | 7.6 ± 0.6 | 6.8 ± 0.4 | −1 |