Table 4 Signaling pathway enrichment analysis of DMGs in periodontitis tissues
From: Comprehensive analysis of DNA methylation for periodontitis
Pathway identifier | Term | Regulation | Count | p value |
|---|---|---|---|---|
hsa05100 | Bacterial invasion of epithelial cells | Hyper-methylated | 3 | 0.017267317 |
hsa04071 | Sphingolipid signaling pathway | Hyper-methylated | 3 | 0.038486205 |
R-HSA-418885 | DCC mediated attractive signaling | Hyper-methylated | 2 | 0.034928066 |
hsa05200 | Pathways in cancer | Hypo-methylated | 31 | 3.04E-06 |
hsa04080 | Neuroactive ligand–receptor interaction | Hypo-methylated | 20 | 8.45E-04 |
hsa04151 | PI3K–Akt signaling pathway | Hypo-methylated | 18 | 0.0369 |
hsa04022 | cGMP–PKG signaling pathway | Hypo-methylated | 15 | 3.04E-06 |
hsa04015 | Rap1 signaling pathway | Hypo-methylated | 15 | 0.0053 |
R-HSA-5673001 | RAF/MAP kinase cascad | Hypo-methylated | 14 | 6.21E-05 |
R-HSA-416476 | G alpha (q) signalling | Hypo-methylated | 14 | 0.001925 |
R-HSA-418594 | R-HSA-418594 | Hypo-methylated | 14 | 0.044195 |
hsa04550 | Signaling pathways regulating pluripotency of stem cells | Hypo-methylated | 13 | 0.0012 |
hsa04020 | Calcium signaling pathway | Hypo-methylated | 13 | 0.0091 |
hsa04062 | Chemokine signaling pathway | Hypo-methylated | 13 | 0.0121 |
hsa04810 | Regulation of actin cytoskeleton | Hypo-methylated | 13 | 0.0287 |
hsa04360 | Axon guidance | Hypo-methylated | 12 | 0.0018 |
hsa04921 | Oxytocin signaling pathway | Hypo-methylated | 12 | 0.0064 |
hsa04724 | Glutamatergic synapse | Hypo-methylated | 11 | 0.0026 |
hsa04728 | Dopaminergic synapse | Hypo-methylated | 11 | 0.006 |
hsa04390 | Hippo signaling pathway | Hypo-methylated | 11 | 0.0179 |
R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K | Hypo-methylated | 10 | 1.03E-04 |
R-HSA-1257604 | PIP3 activates AKT signaling | Hypo-methylated | 10 | 8.96E-04 |
hsa04713 | Circadian entrainment | Hypo-methylated | 10 | 0.0025 |
hsa04916 | Melanogenesis | Hypo-methylated | 10 | 0.0035 |
hsa04723 | Retrograde endocannabinoid signaling | Hypo-methylated | 10 | 0.0038 |
hsa04540 | Gap junction | Hypo-methylated | 9 | 0.0055 |
hsa04915 | Estrogen signaling pathway | Hypo-methylated | 9 | 0.0111 |
R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | Hypo-methylated | 8 | 0.004679 |
hsa04971 | Gastric acid secretion | Hypo-methylated | 8 | 0.007 |
hsa04925 | Aldosterone synthesis and secretion | Hypo-methylated | 8 | 0.0121 |
hsa05100 | Bacterial invasion of epithelial cells | Hypo-methylated | 7 | 0.0326 |
hsa04727 | GABAergic synapse | Hypo-methylated | 7 | 0.0466 |
R-HSA-109704 | PI3K Cascade | Hypo-methylated | 6 | 0.004858 |
R-HSA-373080 | Class B/2 (Secretin family receptors) | Hypo-methylated | 6 | 0.016312 |
hsa04710 | Circadian rhythm | Hypo-methylated | 6 | 0.0023 |
hsa05217 | Basal cell carcinoma | Hypo-methylated | 6 | 0.0247 |
hsa04923 | Regulation of lipolysis in adipocytes | Hypo-methylated | 6 | 0.0284 |
hsa04730 | Long-term depression | Hypo-methylated | 6 | 0.0368 |
hsa04924 | Renin secretion | Hypo-methylated | 6 | 0.0466 |
R-HSA-170670 | Adenylate cyclase inhibitory pathway | Hypo-methylated | 4 | 0.008461 |
R-HSA-112043 | PLC beta mediated events | Hypo-methylated | 4 | 0.012432 |
R-HSA-1566948 | Elastic fibre formation | Hypo-methylated | 4 | 0.017303 |
R-HSA-373752 | Netrin-1 signaling | Hypo-methylated | 4 | 0.020083 |
R-HSA-381426 | Regulation of Insulin-like Growth Factor | Hypo-methylated | 4 | 0.026335 |
hsa04950 | Maturity onset diabetes of the young | Hypo-methylated | 4 | 0.0446 |
hsa04340 | Hedgehog signaling pathway | Hypo-methylated | 4 | 0.049 |
h_rac1Pathway | Rac 1 cell motility signaling pathway | Hypo-methylated | 4 | 0.038391 |
R-HSA-5362798 | Release of Hh-Np from the secreting cell | Hypo-methylated | 3 | 0.023963 |
R-HSA-3371599 | Defective HLCS causes multiple carboxylase deficiency | Hypo-methylated | 3 | 0.023963 |
R-HSA-170660 | Adenylate cyclase activating pathway | Hypo-methylated | 3 | 0.036964 |
R-HSA-196780 | Biotin transport and metabolism | Hypo-methylated | 3 | 0.044264 |
R-HSA-2243919 | Crosslinking of collagen fibrils | Hypo-methylated | 3 | 0.044264 |
h_akap13Pathway | Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation | Hypo-methylated | 3 | 0.049203 |