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Table 4 Signaling pathway enrichment analysis of DMGs in periodontitis tissues

From: Comprehensive analysis of DNA methylation for periodontitis

Pathway identifier Term Regulation Count p value
hsa05100 Bacterial invasion of epithelial cells Hyper-methylated 3 0.017267317
hsa04071 Sphingolipid signaling pathway Hyper-methylated 3 0.038486205
R-HSA-418885 DCC mediated attractive signaling Hyper-methylated 2 0.034928066
hsa05200 Pathways in cancer Hypo-methylated 31 3.04E-06
hsa04080 Neuroactive ligand–receptor interaction Hypo-methylated 20 8.45E-04
hsa04151 PI3K–Akt signaling pathway Hypo-methylated 18 0.0369
hsa04022 cGMP–PKG signaling pathway Hypo-methylated 15 3.04E-06
hsa04015 Rap1 signaling pathway Hypo-methylated 15 0.0053
R-HSA-5673001 RAF/MAP kinase cascad Hypo-methylated 14 6.21E-05
R-HSA-416476 G alpha (q) signalling Hypo-methylated 14 0.001925
R-HSA-418594 R-HSA-418594 Hypo-methylated 14 0.044195
hsa04550 Signaling pathways regulating pluripotency of stem cells Hypo-methylated 13 0.0012
hsa04020 Calcium signaling pathway Hypo-methylated 13 0.0091
hsa04062 Chemokine signaling pathway Hypo-methylated 13 0.0121
hsa04810 Regulation of actin cytoskeleton Hypo-methylated 13 0.0287
hsa04360 Axon guidance Hypo-methylated 12 0.0018
hsa04921 Oxytocin signaling pathway Hypo-methylated 12 0.0064
hsa04724 Glutamatergic synapse Hypo-methylated 11 0.0026
hsa04728 Dopaminergic synapse Hypo-methylated 11 0.006
hsa04390 Hippo signaling pathway Hypo-methylated 11 0.0179
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K Hypo-methylated 10 1.03E-04
R-HSA-1257604 PIP3 activates AKT signaling Hypo-methylated 10 8.96E-04
hsa04713 Circadian entrainment Hypo-methylated 10 0.0025
hsa04916 Melanogenesis Hypo-methylated 10 0.0035
hsa04723 Retrograde endocannabinoid signaling Hypo-methylated 10 0.0038
hsa04540 Gap junction Hypo-methylated 9 0.0055
hsa04915 Estrogen signaling pathway Hypo-methylated 9 0.0111
R-HSA-1650814 Collagen biosynthesis and modifying enzymes Hypo-methylated 8 0.004679
hsa04971 Gastric acid secretion Hypo-methylated 8 0.007
hsa04925 Aldosterone synthesis and secretion Hypo-methylated 8 0.0121
hsa05100 Bacterial invasion of epithelial cells Hypo-methylated 7 0.0326
hsa04727 GABAergic synapse Hypo-methylated 7 0.0466
R-HSA-109704 PI3K Cascade Hypo-methylated 6 0.004858
R-HSA-373080 Class B/2 (Secretin family receptors) Hypo-methylated 6 0.016312
hsa04710 Circadian rhythm Hypo-methylated 6 0.0023
hsa05217 Basal cell carcinoma Hypo-methylated 6 0.0247
hsa04923 Regulation of lipolysis in adipocytes Hypo-methylated 6 0.0284
hsa04730 Long-term depression Hypo-methylated 6 0.0368
hsa04924 Renin secretion Hypo-methylated 6 0.0466
R-HSA-170670 Adenylate cyclase inhibitory pathway Hypo-methylated 4 0.008461
R-HSA-112043 PLC beta mediated events Hypo-methylated 4 0.012432
R-HSA-1566948 Elastic fibre formation Hypo-methylated 4 0.017303
R-HSA-373752 Netrin-1 signaling Hypo-methylated 4 0.020083
R-HSA-381426 Regulation of Insulin-like Growth Factor Hypo-methylated 4 0.026335
hsa04950 Maturity onset diabetes of the young Hypo-methylated 4 0.0446
hsa04340 Hedgehog signaling pathway Hypo-methylated 4 0.049
h_rac1Pathway Rac 1 cell motility signaling pathway Hypo-methylated 4 0.038391
R-HSA-5362798 Release of Hh-Np from the secreting cell Hypo-methylated 3 0.023963
R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency Hypo-methylated 3 0.023963
R-HSA-170660 Adenylate cyclase activating pathway Hypo-methylated 3 0.036964
R-HSA-196780 Biotin transport and metabolism Hypo-methylated 3 0.044264
R-HSA-2243919 Crosslinking of collagen fibrils Hypo-methylated 3 0.044264
h_akap13Pathway Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation Hypo-methylated 3 0.049203