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Table 2 Perioperative management of patients taking DOAK during elective interventions (based on [101])

From: Bleeding disorders in implant dentistry: a narrative review and a treatment guide

Duration of DOAC interruption
  Dabigatran Rivaroxaban, apixaban, edoxaban
Surgical bleeding risk Surgical bleeding risk
Creatinine-clearance Low High Low High
Recommended time of DOAC interruption before surgery Recommended time of DOAC interruption before surgery
 ≥ 80 ml min  ≥ 24 h  ≥ 48 h  ≥ 24 h  ≥ 48 h
50–79 ml/min  ≥ 36 h  ≥ 72 h  ≥ 24 h  ≥ 48 h
30–49 ml/min  ≥ 48 h  ≥ 96 h  ≥ 24 h  ≥ 48 h
 < 30 ml/min No sufficient evidence  ≥ 36 h  ≥ 48 h