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Table 1 Different types of von Willebrand disease (VWD)

From: Bleeding disorders in implant dentistry: a narrative review and a treatment guide

Type 1 Quantitative deficiency of VWF 80% of patients
Type 2 A Qualitative deficiency of VWF with reduced binding ability of VWF to platelets and collagen and reduced high molecular monomers 15–20% of patients
B Qualitative deficiency of VWF with increased affinity for platelet-derived GPIb-receptor and reduced high molecular monomers
M Reduced affinity to platelets with a functional defect in primary hemostasis and decreased ratio of ristocetin cofactor activity to VWF antigen
N Reduced affinity for factor VIII
Type 3 Complete absence or severe reduction of VWF 0.5–1.5% of patients
  1. The VWD is divided into three types (with four subtypes of type 2). In type 1 and 3, von Willebrand factor (VWF) is quantitatively decreased. In type 2 (A,B,M,N) the VWF is qualitatively defective