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Table 1 Different types of von Willebrand disease (VWD)

From: Bleeding disorders in implant dentistry: a narrative review and a treatment guide

Type 1

Quantitative deficiency of VWF

80% of patients

Type 2

A

Qualitative deficiency of VWF with reduced binding ability of VWF to platelets and collagen and reduced high molecular monomers

15–20% of patients

B

Qualitative deficiency of VWF with increased affinity for platelet-derived GPIb-receptor and reduced high molecular monomers

M

Reduced affinity to platelets with a functional defect in primary hemostasis and decreased ratio of ristocetin cofactor activity to VWF antigen

N

Reduced affinity for factor VIII

Type 3

Complete absence or severe reduction of VWF

0.5–1.5% of patients

  1. The VWD is divided into three types (with four subtypes of type 2). In type 1 and 3, von Willebrand factor (VWF) is quantitatively decreased. In type 2 (A,B,M,N) the VWF is qualitatively defective