Table 1 PRISMA checklist

Title

Title

1

Identify the report as a systematic review

Headline

Abstract

Abstract

2

See the PRISMA 2020 for Abstracts checklist

–

Introduction

Rationale

3

Describe the rationale for the review in the context of existing knowledge

Last sentence of introduction

Objectives

4

Provide an explicit statement of the objective(s) or question(s) the review addresses

Last sentence of introduction

Methods

Eligibility criteria

5

Specify the inclusion and exclusion criteria for the review and how studies were grouped for the syntheses

M&M, Study inclusion and exclusion criteria

Information sources

6

Specify all databases, registers, websites, organisations, reference lists and other sources searched or consulted to identify studies. Specify the date when each source was last searched or consulted

M&M, search strategies

Search strategy

7

Present the full search strategies for all databases, registers and websites, including any filters and limits used

M&M, search strategies

Selection process

8

Specify the methods used to decide whether a study met the inclusion criteria of the review, including how many reviewers screened each record and each report retrieved, whether they worked independently, and if applicable, details of automation tools used in the process

M&M, search strategies, first sentence

Data collection process

9

Specify the methods used to collect data from reports, including how many reviewers collected data from each report, whether they worked independently, any processes for obtaining or confirming data from study investigators, and if applicable, details of automation tools used in the process

M&M, search strategies, first sentence

Data items

10a

List and define all outcomes for which data were sought. Specify whether all results that were compatible with each outcome domain in each study were sought (e.g., for all measures, time points, analyses), and if not, the methods used to decide which results to collect

M&M, search strategies, second sentence

10b

List and define all other variables for which data were sought (e.g., participant and intervention characteristics, funding sources). Describe any assumptions made about any missing or unclear information

M&M, search strategies, second sentence

Study risk of bias assessment

11

Specify the methods used to assess risk of bias in the included studies, including details of the tool(s) used, how many reviewers assessed each study and whether they worked independently, and if applicable, details of automation tools used in the process

M&M, Quality and risk of bias assessment of selected studies; Tables 2/3

Effect measures

12

Specify for each outcome the effect measure(s) (e.g., risk ratio, mean difference) used in the synthesis or presentation of results

No effect measures were used due to heterogenous study designs

Synthesis methods

13a

Describe the processes used to decide which studies were eligible for each synthesis (e.g., tabulating the study intervention characteristics and comparing against the planned groups for each synthesis (item #5))

M&M, study selection, Sentence 6

13b

Describe any methods required to prepare the data for presentation or synthesis, such as handling of missing summary statistics, or data conversions

M&M, Quality and risk of bias assessment of selected studies

13c

Describe any methods used to tabulate or visually display results of individual studies and syntheses

M&M, Quality and risk of bias assessment of selected studies, last paragraph

13d

Describe any methods used to synthesize results and provide a rationale for the choice(s). If meta-analysis was performed, describe the model(s), method(s) to identify the presence and extent of statistical heterogeneity, and software package(s) used

M&M, Quality and risk of bias assessment of selected studies, last paragraph

13e

Describe any methods used to explore possible causes of heterogeneity among study results (e.g., subgroup analysis, meta-regression)

M&M, Quality and risk of bias assessment of selected studies, last paragraph

13f

Describe any sensitivity analyses conducted to assess robustness of the synthesized results

No sensitivity analysis has been performed

Reporting bias assessment

14

Describe any methods used to assess risk of bias due to missing results in a synthesis (arising from reporting biases)

M&M, Quality and risk of bias assessment of selected studies, Risk of bias tools

Certainty assessment

15

Describe any methods used to assess certainty (or confidence) in the body of evidence for an outcome

M&M, Quality and risk of bias assessment of selected studies, Clinical studies, penultimate paragraph; Table 3

Results

Study selection

16a

Describe the results of the search and selection process, from the number of records identified in the search to the number of studies included in the review, ideally using a flow diagram

Figure 1

16b

Cite studies that might appear to meet the inclusion criteria, but which were excluded, and explain why they were excluded

Figure 1, Results, Study selection, 3rd section

Study characteristics

17

Cite each included study and present its characteristics

Table 6

Risk of bias in studies

18

Present assessments of risk of bias for each included study

Tables 2/3/5

Results of individual studies

19

For all outcomes, present, for each study: (a) summary statistics for each group (where appropriate) and (b) an effect estimate and its precision (e.g., confidence/credible interval), ideally using structured tables or plots

Table 6

Results of syntheses

20a

For each synthesis, briefly summarise the characteristics and risk of bias among contributing studies

Tables 2/3/5

20b

Present results of all statistical syntheses conducted. If meta-analysis was done, present for each the summary estimate and its precision (e.g., confidence/credible interval) and measures of statistical heterogeneity. If comparing groups, describe the direction of the effect

No statistical analysis has been performed

20c

Present results of all investigations of possible causes of heterogeneity among study results

Tables 3/5

20d

Present results of all sensitivity analyses conducted to assess the robustness of the synthesized results

No sensitivity analysis has been performed

Reporting biases

21

Present assessments of risk of bias due to missing results (arising from reporting biases) for each synthesis assessed

M&M, Quality and risk of bias assessment of selected studies, Clinical studies

Certainty of evidence

22

Present assessments of certainty (or confidence) in the body of evidence for each outcome assessed

Table 3

Discussion

Discussion

23a

Provide a general interpretation of the results in the context of other evidence

Conclusion section

23b

Discuss any limitations of the evidence included in the review

First part of the conclusion

23c

Discuss any limitations of the review processes used

First part of the conclusion

23d

Discuss implications of the results for practice, policy, and future research

Conclusion, last part

Other information

Registration and protocol

24a

Provide registration information for the review, including register name and registration number, or state that the review was not registered

M&M, first part

24b

Indicate where the review protocol can be accessed, or state that a protocol was not prepared

M&M, first part

24c

Describe and explain any amendments to information provided at registration or in the protocol

–

Support

25

Describe sources of financial or non-financial support for the review, and the role of the funders or sponsors in the review

No fundings/Funding section

Competing interests

26

Declare any competing interests of review authors

No conflicts of interest/Competing interests section

Availability of data, code and other materials

27

Report which of the following are publicly available and where they can be found: template data collection forms; data extracted from included studies; data used for all analyses; analytic code; any other materials used in the review

M&M, search strategies