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Table 7 Soft tissue healing outcomes in the evaluated studies

From: Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

Study n Test Control Method Results test Results control Statistics
Sharma et al. [54] 30 PRF Spontaneous healing The Landry wound healing index (mean ± SD) Day 3: 3.43 ± 0.504
Day 7: 3.93 ± 0.254
Day 14: 4.83 ± 0.379
Day 3: 3.17 ± 0.379
Day 7: 3.73 ± 0.082
Day 14: 4.3 ± 0.46
Day 3: yes
p = 0.025
Day 7: yes
P = 0.039
Day 14: yes
p = 0.00
Mourao et al. [56] 32 L-PRF Spontaneous healing Wound healing index (mean ± SD) Week 1: 3.81 ± 0.65
Week 2: 4.75 ± 0.44
Week 1: 3.18 ± 0.54
Week 2: 4.5 ± 0.51
Week 1: Yes
p = 0.0138
Week 2: No
Srinivas et al. [48] 30 PRF Spontaneous healing Wound healing index after 7 days 3.8 ± 0.40 3.0 ± 0.53 Yes
P < 0.001
Ahmed et al. [53]    Spontaneous healing Wound healing index Very good 94.1% Very good in 86.7% Not reported
Ustaoglu et al. [42] 57 L-PRF Spontaneous healing The Landry wound healing index (mean ± SD) Week 1: 3.58 ± 0.63
Week 2: 4.59 ± 0.51
Week 1: 3.21 ± 0.66
Week 2: 4.38 ± 0.49
Week 1: no
Week 2: no
    Spontaneous healing Complete wound epithelization (%) Week 1: 54.9
Week 2: 100
Week 1: 10.1
Week 2: 40.7
Week 1: yes
P = 0.047
Week 2: yes
P = 0.041
   T-PRF Spontaneous healing The Landry wound healing index (mean ± SD) Week 1: 3.69 ± 0.51
Week 2: 4.71 ± 0.50
Week 1: 3.21 ± 0.66
Week 2: 4.38 ± 0.49
Week 1: no
Week 2: no
    Spontaneous healing Complete wound epithelization (%) Week 1: 70.1
Week 2: 100
Week 1: 10.1
Week 2: 40.7
Week 1: yes
P = 0.047
Week 2: yes
P = 0.041
Giudice et al. [40] 40 A-PRF +  Spontaneous healing Wound healing index (mean) Week 1: 1
Week 2: 0.25
Week 1: 1.05
Week 2: 0.33
No
   L-PRF Spontaneous healing Wound healing index (mean) Week 1: 0.95
Week 2: 0.15
Week 1: 1.05
Week 2: 0.33
No
Asmael et al. [58] 20 PRF Spontaneous healing Percentage of epithelization after 1 week 52.7% 51.3% No
     The Landry wound healing index (mean) after 1 week 3.45 4.2 Yes
P = 0.0035
15
Marenzi et al. [57]
  L-PRF Spontaneous healing Wound healing index (mean ± SD) Day 3: 4.8 ± 0.6
Day 7: 4.5 ± 0.5
Day 14: 4.2 ± 0.2
Day 21: 4.1 ± 0.1
Day 3: 5.1 ± 0.9
Day 7: 4.9 ± 0.3
Day 14: 4.3 ± 0.3
Day 21: 4.2 ± 0.2
Day 3: No p = 0.197
Day 7: yes p = 0.05
Day 14: yes p = 0.01
Day 21: yes p = 0.0002