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Table 1 Included studies characteristics

From: Dental implants and risk of bleeding in patients on oral anticoagulants: a systematic review and meta-analysis

Study Study type Participants (n) Evidence level [18] Maximum implants placed per participant (n) Implant brand/type placed Mucoperiosteal flap raised or flapless surgery Immediate or delayed loading Bleeding events reported (total number anticoagulated) c Bone graft (n)
Manor 2020 [6] Retrospective observational cohort study 193 2b Not reported Not reported Mucoperiosteal flap Delayed 4 d (72) 27
Sannino 2020 [12] Case-control study 120 3b 4 (full arch) CSR-DAT, Sweden & Martina, Due Carrare, Italy Mucoperiosteal flap posteriorly only Immediate Control: 1e (40)
Case: 11a (40)
Case: 3b (40)
None reported
Galletti 2020 [11] Retrospective observational cohort study 12 2b 4-6 (full arch) Ossean®; Intra-Lock International®, Inc., Boca Raton, FL, USA Mucoperiosteal flap Immediate 3b (12) Not specified how many grafted
Okamoto 2018 [17] Retrospective observational cohort study 289 2b 1-6 Not reported Not reported Not Reported 4a(19) Patients excluded if grafted
Gomez-Moreno 2018 [14] Case-control study 71 3b Number of implants per patient not specified Straumann® AG, 8, 10 or 12 mm in length and 3.3 or 4.1 mm in diameter. Mucoperiosteal flap Delayed Control: 2 (42)
Case : 2f (29)
Control: 9
Case: none reported
Clemm 2016 [15] Case-control study 564 3b Number of implants per patient not specified Not reported Mucoperiosteal flap Delayed Control: 3 (447)
Case: 4d (117)
Control: 77
Case : 16
Gomez-Moreno 2016 [13] Case-control study 57 3b 1-3 Straumann® AG, 8, 10 or 12 mm in length and 3.3 or 4.1 mm in diameter. Mucoperiosteal flap Delayed Control: 2d (39)
Case: 1b (18)
Control: 9
Case: none reported
Bacci 2011 [16] Case-control study 161 3b Number of implants per patient not specified Not reported Mucoperiosteal flap Delayed Control: 3 (109)
Case: 2a (52)
Control: 66 (implants)
Case: 30 (implants)
  1. aWarfarin | bRivaroxaban | cModerate events | d Combination of DOACs/warfarin or antiplatelets | eNo anticoagulant | fDabigatran