Dental implants and risk of bleeding in patients on oral anticoagulants: a systematic review and meta-analysis

Dawoud, Basim E. S.; Kent, Samuel; Tabbenor, Oliver; George, Pynadath; Dhanda, Jagtar

doi:10.1186/s40729-021-00364-5

International Journal of Implant Dentistry

Table 1 Included studies characteristics

From: Dental implants and risk of bleeding in patients on oral anticoagulants: a systematic review and meta-analysis

Study	Study type	Participants (n)	Evidence level [18]	Maximum implants placed per participant (n)	Implant brand/type placed	Mucoperiosteal flap raised or flapless surgery	Immediate or delayed loading	Bleeding events reported (total number anticoagulated) ^c	Bone graft (n)
Manor 2020 [6]	Retrospective observational cohort study	193	2b	Not reported	Not reported	Mucoperiosteal flap	Delayed	4 ^d (72)	27
Sannino 2020 [12]	Case-control study	120	3b	4 (full arch)	CSR-DAT, Sweden & Martina, Due Carrare, Italy	Mucoperiosteal flap posteriorly only	Immediate	Control: 1^e (40) Case: 11^a (40) Case: 3^b (40)	None reported
Galletti 2020 [11]	Retrospective observational cohort study	12	2b	4-6 (full arch)	Ossean®; Intra-Lock International®, Inc., Boca Raton, FL, USA	Mucoperiosteal flap	Immediate	3^b (12)	Not specified how many grafted
Okamoto 2018 [17]	Retrospective observational cohort study	289	2b	1-6	Not reported	Not reported	Not Reported	4^a(19)	Patients excluded if grafted
Gomez-Moreno 2018 [14]	Case-control study	71	3b	Number of implants per patient not specified	Straumann® AG, 8, 10 or 12 mm in length and 3.3 or 4.1 mm in diameter.	Mucoperiosteal flap	Delayed	Control: 2 (42) Case : 2^f (29)	Control: 9 Case: none reported
Clemm 2016 [15]	Case-control study	564	3b	Number of implants per patient not specified	Not reported	Mucoperiosteal flap	Delayed	Control: 3 (447) Case: 4^d (117)	Control: 77 Case : 16
Gomez-Moreno 2016 [13]	Case-control study	57	3b	1-3	Straumann® AG, 8, 10 or 12 mm in length and 3.3 or 4.1 mm in diameter.	Mucoperiosteal flap	Delayed	Control: 2^d (39) Case: 1^b (18)	Control: 9 Case: none reported
Bacci 2011 [16]	Case-control study	161	3b	Number of implants per patient not specified	Not reported	Mucoperiosteal flap	Delayed	Control: 3 (109) Case: 2^a (52)	Control: 66 (implants) Case: 30 (implants)

^aWarfarin | ^bRivaroxaban | ^cModerate events | ^d Combination of DOACs/warfarin or antiplatelets | ^eNo anticoagulant | ^fDabigatran

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