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International Journal of Implant Dentistry
Fig. 6 | International Journal of Implant Dentistry

Fig. 6

From: The extract of concentrated growth factor enhances osteogenic activity of osteoblast through PI3K/AKT pathway and promotes bone regeneration in vivo

Fig. 6

Immunohistochemical analysis of the expression of VEGF and OCN. At 2 weeks, immunohistochemistry revealed weak intercellular expressions of VEGF and OCN in groups C and B; in group BC, the expressions were more obvious. At 6 weeks, obvious intercellular expressions of VEGF and OCN could be seen in groups C and B; in group BC, the cells were strongly positive for VEGF and OCN. The immunostaining sections were observed under a light microscope at ×200 magnification. Group C, unfilled defect for control; group B, bone collagen alone; group BC, CGF-e + bone collagen. Quantitative analysis showed that the mean density (MD) of VEGF and OCN of BC group was significantly higher than C and B groups. *p < 0.05; **p < 0.01

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