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International Journal of Implant Dentistry
Fig. 4 | International Journal of Implant Dentistry

Fig. 4

From: The extract of concentrated growth factor enhances osteogenic activity of osteoblast through PI3K/AKT pathway and promotes bone regeneration in vivo

Fig. 4

HE staining analysis of the bone regeneration of critical-sized rat cranial defects. At 2 weeks, loose fibro-collagenous stroma and irregularly arranged cells could be seen at the edge of defect area in groups B and C, while new bone formation could be observed in group BC, which was limited to the area of the defect margin. At 6 weeks, only a small amount of new bone could be seen in group C; in group B, obvious new bone formation was seen, extending along the edge of the bone graft material; in group BC, a large amount of new bone formation was seen, extending from the old bone defect to the center of the bone defect, surrounding bone graft material. Group C, unfilled defect for control; group B, bone collagen alone; group BC, CGF-e + bone collagen. The histological images were photographed under a light microscope at ×40 and ×200 magnifications. (Black asterisk: new bone tissue) Quantitative analysis showed that the area of new bone formation (NBF) of the BC group was significantly higher than C and B groups. *p < 0.05; **p < 0.01

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