Fig. 1

Regions of interest and tissue classes in the histomorphometric analysis. The defect area is divided (yellow) into three regions of interest: a central defect area (CD) between the defect edges, an ectocranial defect area (ED) directly above the central defect area, and two ectocranial defect edges (EE) laterally to the ectocranial defect area in both directions. Bone with collagen (royal blue fill), bone without collagen (light blue), and mineralized collagen fibers (pink) are quantified