Fig. 3

Representative histological and immunohistochemical views of tissue reactions in the De and De+Be groups. a De specimens commonly presented with well discernible ICT areas that were larger in size (HE stain). b A higher frequency of CD68-positive cells was also commonly noted outside the ICT areas (De group). c An infiltration of the epithelial compartment associated with a surface ulceration was occasionally noted in both De groups (De+Be group). d Specimen showing a massive infiltration of the connective tissue compartment with CD68-positive cells (De+Be group)