Outcomes | Groups | Follow-ups | 24 h–7 days | 7–21 days | ||||
---|---|---|---|---|---|---|---|---|
24-h | 7-day | 21-day | p-valueb | Effect sizeb | p-valueb | Effect sizeb | ||
Pain in the surgical area | 1-IOD | 40 (40) | 20 (20) | 0 (10) | 0.012 | − 0.53 | < 0.001 | − 0.74 |
2-IOD | 50 (65) | 30 (50) | 5 (28) | 0.001 | − 0.69 | 0.002 | − 0.64 | |
p-valuea | 0.243 | 0.400 | 0.188 | |||||
Pain when chewing | 1-IOD | 40 (40) | 20 (20) | 10 (20) | 0.006 | − 0.57 | 0.059 | − 0.39 |
2-IOD | 40 (78) | 20 (50) | 10 (20) | 0.001 | − 0.66 | 0.008 | − 0.54 | |
p-valuea | 0.472 | 0.820 | 0.812 | |||||
Swelling | 1-IOD | 0 (10) | 0 (10) | 0 (0) | 0.020 | − 0.49 | 0.439 | − 0.16 |
2-IOD | 10 (28) | 0 (10) | 0 (0) | 0.011 | − 0.52 | 0.067 | − 0.37 | |
p-valuea | 0.045 | 0.361 | 0.706 | |||||
Bleeding | 1-IOD | 10 (10) | 0 (0) | 0 (0) | 0.003 | − 0.62 | 0.713 | − 0.08 |
2-IOD | 10 (20) | 0 (8) | 10 (10) | 0.009 | − 0.54 | 0.020 | − 0.48 | |
p-valuea | 0.669 | 0.320 | 0.307 | |||||
Unpleasantness | 1-IOD | 30 (40) | 20 (30) | 10 (10) | 0.008 | − 0.55 | 0.098 | − 0.35 |
2-IOD | 45 (60) | 25 (50) | 20 (40) | < 0.001 | − 0.73 | 0.033 | − 0.44 | |
p-valuea | 0.243 | 0.536 | 0.474 | |||||
Overall score | 1-IOD | 24 (26) | 14 (14) | 4 (16) | < 0.001 | − 0.76 | 0.009 | − 0.54 |
2-IOD | 41 (37) | 18 (32) | 8 (17.5) | < 0.001 | − 0.82 | 0.001 | − 0.68 | |
p-valuea | 0.365 | 0.353 | 0.443 |