Table 3 Eligibility criteria

• Studies including human subjects in good general health (patient/population)

• Partially or fully edentulous patients (patient/population)

• No restriction on age or gender (patient/population)

• Restorations supported by osseointegrated implants with no restriction on material, design, number, location, surgical technique and loading protocol (intervention)

• Intervention and comparison group, FISP versus RISP (comparison)

• Marginal bone loss around maxillary and mandibular implants, with no restriction on the location (outcome)

• Validated, standardized measurement methods to investigate MBL (outcome)

• Randomized controlled trials (RCTs), quasi randomized controlled trials (qRCTs), prospective and retrospective studies (study design)

• Publications in English or German with no restriction on date (study design)

• Unpublished work

• Patients with diabetes, periodontal diseases, pregnancy, osteoporosis, heavy smokers and studies in which >25% of the patient population were smokers

• Studies with less than 15 patients

• Patients with augmented bone

• Tooth-implant-supported restorations

• Single-tooth implant restorations

• Studies including animals and in vitro studies