Morphometric parameters | Baseline line (T0) | 3 months (T1) | 6 months (T2) | ||||||
---|---|---|---|---|---|---|---|---|---|
Unit | DBBM-C | LBMB | Untreated | DBBM-C | LBMB | Untreated | DBBM-C | LBMB | |
Bone mineral density | mg HA/cm3 | 310.56 (44.52)c | 286.24 (74.6) | 442.55 (81.52) | 362.88 (93.81) | 368.62 (57.58) | 419.82 (71.51) | 442.1 (63.66)c | 363.97 (5.05) |
Bone volume fraction | (%) | 53.86 (7.57)a | 31.2 (6.68)a | 22.47 (7.15)b | 57.18 (16.57)b,a | 38.94 (7.87)b,a | 22.54 (6.52) | 47.20 (25.64) | 33.09 (12.46) |
Bone surface density | (mm2/mm3) | 6.55 (0.66)a,c | 4.69 (1.02)a,c | 1.72 (0.50)b | 5.20 (0.85)b | 4.25 (0.80)b | 1.64 (0.29)b | 3.76 (1.34)b,c | 3.24 (0.64)b,c |
Trabecular thickness | (mm) | 0.27 (0.02) | 0.22 (0.03) | 0.47 (0.06) | 0.37 (0.10) | 0.37 (0.12) | 0.58 (0.15) | 0.44 (0.15) | 0.38 (0.09) |
Trabecular number | (1/mm) | 1.19 (0.24)a,c | 1.41 (0.26)a,c | 0.47 (0.13)b | 1.52 (0.19)b,a | 1.10 (0.31)b,a | 0.38 (0.04)b | 1.04 (0.49)b,c | 0.84 (0.19)c |
Trabecular separation | (mm) | 0.30 (0.10)a | 0.51 (0.12)a | 1.55 (0.47)b | 0.35 (0.11)b,a | 0.54 (0.15)b,a | 1.31 (0.33)b | 0.68 (0.48)b | 0.80 (0.26) |
Trabecular pattern factor | (1/mm) | − 5.76 (2.56)a | 0.81 (1.14)a | 0.42 (3.63)b | − 5.61 (4.86)b | 0.4 (1.73) | 2.61 (3.05) | − 3.52 (6.28) | 1 (2.64) |
Structural model index | − 0.38 (0.75)a | 0.95 (0.27)a | 0.57 (1.95) | − 1.39 (3.74) | 1.09 (0.56) | 1.80 (1.33) | − 0.54 (2.70) | 1.25 (0.83) | |
Total porosity | (%) | 46.13 (7.57)a | 68.79 (6.68)a | 77.52 (7.15)b | 42.81 (16.57)b,a | 61.05 (7.87)a | 77.45 (6.52) | 52.79 (25.64) | 66.9 (12.46) |
Connective density | (1/mm3) | 20.62 (4.52)a,c | 9.65 (6.58)a | 1.63 (0.88)b | 13.04 (6.14)b | 6.94 (3.08) | 1.24 (0.60)b | 6.78 (4.32)b,c | 3.87 (1.26) |