Fig. 1

Timing of PROM assessments in treatment programme. The PROMS were assessed at pre-defined steps in the treatment programme of an individual participant. First, when a participant was included for the study but before an intervention had taken place, the OHIP-49NL, denture satisfaction and chewing ability questionnaires were administered to determine the baseline level of oral health-related quality of life, satisfaction with the current denture and perceived ability to chew food, respectively. Next, directly following the reconstruction surgery that included the bone graft harvesting from either calvarium or anterior iliac crest, the post-operative pain was assessed by asking participants to report the perceived pain at donor site on a 100-mm VAS score for 30 days. Following a 4-month osseointegration phase, the implants were placed in the reconstructed maxilla. Another 4 months later, the patients received their implant-retained denture. No PROMs were assessed during these two steps as they were not related to the bone graft harvesting surgery. Finally, at a 12-month follow-up meeting, the OHIP-49NL, denture satisfaction and chewing ability questionnaires were administered again to measure improvement or decrease in scores. Moreover, patient satisfaction with the procedure and the outcomes were assessed as well as presence of long-term physical sequelae resulting from the bone graft harvesting procedure