Table 7 Clinical studies that investigated the effect of NSAIDs on osseointegration
Study (year) | Sample (size) | Treatment group (size) | Methodology | Parameter | Outcome |
|---|---|---|---|---|---|
Alissa et al. (2009) [21] | Eligible human patients (n = 61). Implants inserted (n = 132). | Ibuprofen (n = 31), implants (n = 67). Placebo (n = 30), implants (n = 65). | Ibuprofen, 600 mg q.i.d. for 7 days orally | Post-operative radiographic marginal bone height at 3 and 6 months | No statistically significant differences in mean marginal bone level changes at 3 or 6 months. |
Sakka et al. (2013) [24] | Eligible human patients (n = 28). Implants inserted (n = 57). | Ibuprofen (n = 14), implants (n = 31). Non-Ibuprofen (n = 14), implants (n = 26). | Ibuprofen, 600 mg q.i.d. for 7 days orally | Post-operative radiographic marginal bone height at 3 and 6 months | No statistically significant differences in mean marginal bone level changes at 3 or 6 months. |
Winnett et al. (2014) [25] | Patients treated between 1979 and 2012 with failed and surgically removed dental implants | Cohort that used post-operative NSAIDs (n = 60, with 119 failed implants). Cohort that did not use post-operative NSAIDs (n = 44, with 78 failed implants). | Ibuprofen was the most commonly prescribed, 600 mg q.i.d. Other prescribed analgesics were ketorolac, vioxx, celebrex, diflunisal, meloxicam, paracetamol, and naproxen. | Radiographic bone loss. Vertical bone height of remaining implants. | NSAID cohort experienced more implant failures than the non-NSAID cohort. The NSAID cohort experienced more cases of radiographic bone loss greater than 30% of the vertical height of their remaining implants. |