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Table 7 Clinical studies that investigated the effect of NSAIDs on osseointegration

From: The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

Study (year) Sample (size) Treatment group (size) Methodology Parameter Outcome
Alissa et al. (2009) [21] Eligible human patients (n = 61). Implants inserted (n = 132). Ibuprofen (n = 31), implants (n = 67). Placebo (n = 30), implants (n = 65). Ibuprofen, 600 mg q.i.d. for 7 days orally Post-operative radiographic marginal bone height at 3 and 6 months No statistically significant differences in mean marginal bone level changes at 3 or 6 months.
Sakka et al. (2013) [24] Eligible human patients (n = 28). Implants inserted (n = 57). Ibuprofen (n = 14), implants (n = 31). Non-Ibuprofen (n = 14), implants (n = 26). Ibuprofen, 600 mg q.i.d. for 7 days orally Post-operative radiographic marginal bone height at 3 and 6 months No statistically significant differences in mean marginal bone level changes at 3 or 6 months.
Winnett et al. (2014) [25] Patients treated between 1979 and 2012 with failed and surgically removed dental implants Cohort that used post-operative NSAIDs (n = 60, with 119 failed implants). Cohort that did not use post-operative NSAIDs (n = 44, with 78 failed implants). Ibuprofen was the most commonly prescribed, 600 mg q.i.d. Other prescribed analgesics were ketorolac, vioxx, celebrex, diflunisal, meloxicam, paracetamol, and naproxen. Radiographic bone loss. Vertical bone height of remaining implants. NSAID cohort experienced more implant failures than the non-NSAID cohort. The NSAID cohort experienced more cases of radiographic bone loss greater than 30% of the vertical height of their remaining implants.