Arpornmaeklong et al. (2009) [19]
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Mouse calvaria cell line (MC3T3-E1)
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Indomethacin 0.1 μM
Celecoxib 1.5 μM
Celecoxib 3.0 μM
Celecoxib 9.0 μM
Control
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Incubation in treatment medium for 5 days.
Investigations were performed in three experimental phases: static, log, and plateau
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The following parameters were assessed at 1, 3, and 5 days: cell attachment, cell growth, cell differentiation, secretion of PGE2
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Cells were able to grow and attach to titanium surface for all treatment groups.
Indomethacin and celecoxib cell growth on days 3 and 5 in static phase and on day 3 in log phase.
Indomethacin and celecoxib caused a significant decrease PGE2 concentration in static and plateau but not log phases.
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Boyan et al. (2001) [20]
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Human osteosarcoma cell line (MG63)
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Indomethacin 0.1 μM
Resveratrol 1 μM
Resveratrol 10 μM
NS-398 1 μM
NS-398 10 μM
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Incubation in treatment medium for 5 days.
Cells were cultured on tissue culture plastic, smooth titanium, and two rough titanium surfaces: grit-blasted/acid-etched and titanium-plasma sprayed
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The following parameters were assessed after 5 days: osteocalcin content, PGE2 content, and TGF-β1 content.
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Indomethacin, resveratrol, and NS-398 had no effect on osteocalcin content.
Indomethacin and resveratrol blocked PGE2 production. NS-398 had no effect on PGE2 production on smooth surfaces but caused a reduction on rough surfaces.
Indomethacin blocked TGF-β1 production on rough surfaces. Resveratrol blocked TGF-β1 on TPS. NS-398 did not cause TGF-β1 inhibition.
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