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Table 2 Characteristics of selected studies

From: Maxillary sinus augmentation using chairside bone marrow aspirate concentrates for implant site development: a systematic review of histomorphometric studies

Study Treatment groups No. of patients (age range) No. of maxillary sinuses evaluated Donor site for BMAC Clinical findings/implant survival Timing of biopsy Histologic outcomes
de Oliveira et al. [12] SCG (BMAC obtained by single centrifugation and bone graft)
DCG (BMAC obtained by double centrifugation and bone graft)
Control (xenogenous bone graft alone)
15 (mean age 55.4 years) 21 Posterior iliac crest - 68 implants were placed in the previously grafted sites, and 100% osseointegrated
- Loading was applied after 6 months
6 months Vital mineralized tissue:
- SCG 38.44%
- DCG 34.63%
- Control 27.30%
- Not statistically different
Non-vital mineralized tissue:
- SCG 13.70%
- DCG 19.63%
- Control 22.79%
- Not statistically different
Non-mineralized tissue:
- SCG 47.87%
- DCG 45.73%
- Control 49.90%
- Not statistically different
Pasquali et al. [7] Test (BMAC and xenogenous bone graft)
Control (xenogenous bone graft alone)
8 (mean age 55.4 years) 16 Superior posterior iliac crest - At least two implants were placed in each previously grafted sites, and all implants osseointegrated
- Loading was applied after a 6-month healing period
6 months Vital mineralized tissue:
- Test 55.15%
- Control 27.30%
- Statistically significant
Non-vital mineralized tissue:
- Test 6.32%
- Control 22.79%
- Statistically significant
Non-mineralized tissue:
- Test 38.53%
- Control 49.90%
- Not statistically significant
Payer et al. [2] Test (porous bovine bone mineral together with tibial bone marrow aspirate)
Control (bovine bone graft without any additive)
6 (mean age 58.2 years) 12 Tibia - 44 implants were stable and osseointegrated at radiographic and Periotest evaluation 3 months
6 months
Newly formed bone:
3 months
-Test 10.36%
- Control 9.45%
- Not statistically significant
6 months
- Test 14.12%
- Control 10.41%
- Not statistically significant
3 and 6 months:
- Not statistically significant
Bone-to-bone substitute contact:
3 months
-Test 16.40%
- Control 15.06%
- Not statistically significant
6 months
- Test 20.26%
- Control 17.89%
- Not statistically significant
3 and 6 months:
- Not statistically significant
Sauerbier et al. [11] Open bone marrow-derived mononuclear cell isolation by synthetic poylsaccharide (FICOLL) method with bovine bone mineral (BBM)
Closed bone marrow aspirate concentrate (BMAC) system with BBM
FICOLL group 4 (mean age 59.5 years)
BMAC group 7
(mean age 55 years)
FICOLL group 6
BMAC group 12
Superior posterior iliac spine - 50 implants were placed (17 FICOLL group and 33 BMAC group)
- Implant survival was evaluated after 1 year
- No implant out of 17 was lost in the FICOLL group, before prosthetic loading
- 1 implant out of 33 failed in the BMAC group, before prosthetic loading
- No implant was lost after loading
- All 49 osseointegrated implants were loaded and in function
3 months New bone formation:
- FICOLL group 15.5%,
- BMAC group 19.9%,
- Not statistically significant Value of biomaterial:
- FICOLL group 19.7%
- BMAC group 31.9%
Value of marrow space:
- FICOLL group 64.8%
- BMAC group 47.4%
- Marrow space is significantly less for BMAC
 
Sauerbier et al. [14] Test: bovine bone mineral (BMM) and BMAC
Control 70% BBM and autogenous bone 30% harvested from the retromolar area
25 test
11 control (mean age 56.6 years)
34 test
11 control
Superior posterior iliac spine Radiologic gain and augmented bone height:
- Test 1.74%
- Control 1.33%
- Statistically significant
3–4 months New bone formation:
- Test 12.6%
- Control 14.3%
- Not statistically significant
 
Wildburger et al. [15] Test: bovine bone mineral (BBM) mixed with a concentrate harvested from the posterior iliac crest
Control: BBM alone
7 (mean age 58 years) 14 Superior posterior iliac crest - 52 implants were placed
- Average dental
implant healing time was 4 months
- Prosthetic treatment was achieved in all patients
3 months
6 months
New bone formation:
3 months
- Test 7.4%
- Control 11.8%
- Not statistically significant
6 months
- Test 13.5%
- Control 13.9%
- Not statistically significant
Fraction of bovine bone material 3 months
- Test 42.6%
- Control 34.9%
6 months
- Test 36.2%,
- Control 39.5%
  1. BMAC bone marrow aspirate concentrate