Selection bias
|
Was administered dose or exposure level adequately randomized?
|
++
|
++
|
++
|
−−
|
++
|
++
|
Was allocation to study groups adequately concealed?
|
NR
|
NR
|
NR
|
−−
|
+
|
NR
|
Performance bias
|
Were the research personnel and human subjects blinded to the study group during the study?
|
−−
|
−−
|
−−
|
−−
|
+
|
−−
|
Detection bias
|
Can we be confident in the exposure characterization?
|
−
|
−
|
−
|
−
|
−
|
−
|
Can we be confident in the outcome assessment?
|
++
|
++
|
++
|
++
|
++
|
++
|
Attrition bias
|
Were outcome data complete without attrition or exclusion from analysis?
|
++
|
++
|
+
|
++
|
−
|
−
|
Reporting bias
|
Were all measured outcomes reported?
|
++
|
++
|
++
|
++
|
−
|
−
|