Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies

International Journal of Implant Dentistry

Table 2 Included studies and the evaluation methods employed, together with major outcomes for each method

Study		Tests and overall results
Study	Bone mineral density	Histomorphometric	Biomechanical	MicroCT	Nanoindentation	Serum analysis
Maïmoun et al. 2010 [29]	_	_	SRAN > C	SRAN > C (trabecular bone microarchitecture and BIC)	SRAN > C (elastic modulus, tissue hardness, and working energy)	_
Li et al. 2010 [32]	_	_	OVX + SR_H=C_S > OVX + SRAN_L > OVX	OVX + SRAN_H > C_S > OVX + SRAN_L > OVX	_	_
Li et al. 2012 [33]	_	OVX + SRAN > OVX (BIC and BA)	OVX + SRAN > OVX	OVX + SRAN > OVX	_	OVX + SRAN > OVX (OCN) OVX + SRAN < OVX (TRAP)
Linderbäck et al. 2012 [30]	BP_A > SRAN=C (4 and 8 weeks)	BP_A > SRAN=C (4 and 8 weeks)	BP_A > SRAN=C (4 and 8 weeks)	BP_A > SRAN=C (around implant) BP_A > SRAN > C (growth plate)	_	_
Chen et al. 2013 [31]	BP_Z = C_S > BP_A = SRAN > OVX	BP_Z = C_S > BP_A = SRAN > OVX	BP_Z = C_S > BP_A = SRAN > OVX	_	_	_

C_S sham operation as a control positive group, C control, SRAN strontium ranelate, OVX ovariectomy, SRAN_L strontium ranelate low dose, SR_H strontium ranelate high dose, BP bisphosphonate, BP_A alendronate, BP_Z zolendronate, BIC bone contact implant, BA bone area, OCN osteocalcin, TRAP tartrate-resistant acid phosphatase