Table 1 Included studies and sample characteristics. Animal model, study groups, treatment start point and its duration, period of evaluation, implants specification, and evaluation methods
Study | Sample characteristics | |||||
|---|---|---|---|---|---|---|
Animal model | Study groups | Treatment start | Duration of the treatment and period of examination | Implant specification | Evaluation methods | |
Maïmoun et al. 2010 [29] | Female rats | C: 0.5% carboxymethylcellulose aqueous solution (gavage, 5 days a week, n = 15) SRAN: 625 mg/kg of strontium ranelate, for 8 weeks following implantation (gavage, 5 days a week, n = 15) | nd | 8 weeks | 1.0 × 4.1 mm pure titanium, with sand-blasted, acid-etched surface, inserted in the tibial methaphysis, bilaterally | Microtomography, pull-out biomechanical test, and nanoindentation tests |
Li et al. 2010 [32] | Female rats | CS: sham operation as a control group, and did not receive any drug treatments (n = 10) OVX: bilateral ovariectomy 12 weeks before implantation (n = 10) OVX + SRANL: bilateral ovariectomy 12 weeks before implantation, plus special diet providing 500 mg/kg/day of strontium ranelate after implantation (n = 10) OVX + SRANH: bilateral ovariectomy 12 weeks before implantation, plus special diet providing 1000 mg/kg/day of strontium ranelate after implantation (n = 10) | Started on the day of implantation | 12 weeks | 1.8 × 3.5 mm, sand-blasted and with sprayed HA-coating, inserted in the tibiae, unilaterally | Microtomography, push-out biomechanical test |
Li et al. 2012 [33] | Female rats | OVX: bilateral ovariectomy, 12 weeks before implantation (n = 10) OVX + SRAN: bilateral ovariectomy 12 weeks before implantation, plus special diet providing 625 mg/kg/day of strontium ranelate after implantation (n = 10) | Started on the day of implantation | 12 weeks | 1.2 × 10.0 mm commercially pure titanium, machined and grit-blasted with aluminum oxide, inserted in the distal femur, bilaterally | Microtomography, histomorphometric (BA and BIC), serum analysis (OCN and TRAP), and push-out biomechanical test |
Linderbäck et al. 2012 [30] | Male rats | C: normal diet (n = 20) BPA: 20 μg/kg/day subcutaneous alendronate, three times a week (n = 20) SRAN: special diet containing 800 mg/kg/day strontium ranelate (n = 20) | BPA group started within 24 h after implantation SR group started on the day of implantation | 4 and 8 weeks | 1.6 × 2.5 mm stainless steel and polymethyl methacrylate (PMMA) screws, inserted in the tibial methaphysis, bilaterally | Microtomography, pull-out biomechanical test, histomorphometric analysis (BA), and bone mineral analyses (ash weight) |
Chen et al. 2013 [31] | Female rats | CS: sham operation as a control group, and did not receive any drug treatments (n = 12) OVX: bilateral ovariectomy 4 weeks before implantation, and did not receive any drug treatments (n = 11) OVX+BPA: bilateral ovariectomy 4 weeks before implantation, alendronate 7 mg/kg/week orally (n = 10) OVX+SRAN: bilateral ovariectomy 4 weeks before implantation, strontium ranelate 500 mg/kg/day orally (n = 12) OVX+BPZ: bilateral ovariectomy 4 weeks before implantation, single dose of zoledronic acid 0.1 mg/kg intravenous (n = 11) | 1 week after implantation | 11 and 12 weeks | 1.0 × 10.0 mm titanium plasma-sprayed with hydroxyapatite, inserted in the tibial methaphysis, bilaterally | Bone mineral density, histological analysis, and push-out biomechanical test |