|
Treatment arm
|
Summary statistics
|
Baseline
|
6 months
|
Change from baseline to 6 months
|
12 months
|
Change from baseline to 12 months
|
|---|
|
Early loading-arm (N = 38)
|
No. of patients
|
38
|
38
|
38
|
38
|
38
|
|
Mean (SD)
|
1.342 (0.600)
|
1.903 (0.603)
|
0.561a (0.576)
|
2.102 (0.483)
|
0.760b (0.603)
|
|
Maximum
|
2.73
|
2.96
|
2.21
|
3.47
|
2.15
|
|
Third quartile
|
1.73
|
2.22
|
0.88
|
2.34
|
1.14
|
|
Median
|
1.25
|
2.015
|
0.55
|
2.05
|
0.80
|
|
First quartile
|
0.98
|
1.52
|
0.17
|
1.77
|
0.37
|
|
Minimum
|
0.29
|
0.48
|
−0.51
|
1.24
|
−0.39
|
|
Conventional loading arm (N = 37)
|
No. of patients
|
37
|
37
|
37
|
36
|
36
|
|
Mean (SD)
|
1.355 (0.724)
|
1.868 (0.521)
|
0.513b (0.617)
|
2.099 (0.558)
|
0.734b (0.77)
|
|
Maximum
|
3.01
|
3.81
|
1.82
|
3.74
|
2.54
|
|
Third quartile
|
1.85
|
2.07
|
0.94
|
2.45
|
1.185
|
|
Median
|
1.43
|
1.83
|
0.49
|
2.02
|
0.61
|
|
First quartile
|
0.76
|
1.58
|
0.07
|
1.735
|
0.14
|
|
Minimum
|
0.27
|
0.83
|
−0.71
|
1.04
|
−0.66
|
-
aInter-arm difference (6 months): difference in mean 95 % confidence interval 0.048 (−0.227–0.322)
-
bInter-arm difference (6 months): difference in mean 95 % confidence interval 0.026 (−0.293–0.346)
