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Table 8 Included studies—nonsurgical treatment of peri-implantitis: adjunctive antibiotic therapy

From: Efficacy of alternative or adjunctive measures to conventional treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

Publication Design Population Case definition Period Test Control Mean (SD) outcome
Büchter et al. [26] RCT, parallel 28 patients PD >5 mm 18 weeks OHI + mechanical debridement (plastic curettes) + 0.2 % CHX pocket irrigation + 8 % doxycycline hyclate OHI + mechanical debridement (plastic curettes) + 0.2 % CHX pocket irrigation Test
   48 implants medium-rough surfaces Bone loss >50 %     BOP: 0.54 (0.07) (BL) to 0.27 (0.06) % (18 weeks, subject level)
        PD: 5.64 (0.32) (BL) to 4.49 (0.29) mm (18 weeks, subject level)
        Control
        BOP: 0.63 (0.06) (BL) to 0.50 (0.07) % (18 weeks, subject level)
        PD: 5.68 (0.28) (BL) to 5.4 (0.34) mm (18 weeks, subject level)
        BOP and PD reductions sign. higher in the test group
Renvert et al. [32] RCT, parallel 32 patients PD ≥4 mm, BOP + with suppuration 12 months OHI + mechanical debridement (scalers + rubber cup + polishing) + 1 mg minoycycline microspheres OHI + mechanical debridement (scalers + rubber cup + polishing) + 1.0 % chlorhexidine gel Test
   1–5 (test)/1–6 (control) implants per patient machined surfaces Bone loss ≤3 threads     BOP: 88 (12) (BL) to 71 (22) % (12 months, subject level)
    Presence of anaerobic bacteria     PD: 3.9 (0.7) (BL) to 3.6 (0.6) mm (12 months, subject level)
        Control
        BOP: 86 (14) (BL) to 78 (13) % (12 months, subject level)
        PD: 3.9 (0.3) (BL) to 3.9 (0.4) mm (12 months, subject level)
        PD reductions at 12 months sign. higher in the test group
        Comparable microbiological improvements in both groups
Renvert et al. [29] RCT, parallel 32 patients PD ≥4 mm, BOP + with suppuration 12 months OHI + mechanical debridement + 1 mg minoycycline microspheres OHI + mechanical debridement + 0.5 ml of 1.0 % CHXgel Test
   95 implants machined surfaces Bone loss ≤3 threads   Treatment was repeated at days 30 and 90 Treatment was repeated at days 30 and 90 BOP: 86.5 (20.1) (BL) to 48.1 (20.7) % (12 months, implant level)
    Presence of anaerobic bacteria     PD: 3.85 (1.04) (BL) to 3.55 (0.98) mm (12 months, implant level)
        Radiographic bone levels: 0.77 (0.85) (BL) to 0.7 (0.85) mm (12 months, implant level)
        Control
        BOP: 89.2 (17.2) (BL) to 63.5 (19.2) % (12 months, implant level)
        PD: 3.87 (1.16) (BL) to 3.72 (1.02) mm (12 months, implant level)
        Radiographic bone levels: 0.41 (0.7) (BL) to 0.46 (0.76) mm (12 months, implant level)
        BOP reductions at 12 months sign. higher in the test group
        Comparable microbiological improvements in both groups
Schär et al.; Bassetti et al. [34, 37] RCT, parallel 40 patients PD = 4–6 mm, BOP + bone loss = 0.5–2 mm 12 months OHI + mechanical debridement (titanium curettes + glycin powder air polishing, pocket irrigation using 3 % hydrogen peroxide) + aPDT (660 nm, phenothiazine chloride dye) OHI + mechanical debridement (titanium curettes + glycin powder air polishing, pocket irrigation using 3 % hydrogen peroxide) + minocycline microspheres Test
   40 implants medium-rough surfaces      BOP change: 57 % (12 months, subject level)
        PD changes: 0.56 mm (12 months, subject level)
        Complete resolution of mucosal inflammation: 31.6 %
        Control
        BOP change: 65 % (12 months, subject level)
        PD changes: 0.11 mm (12 months, subject level)
        Complete resolution of mucosal inflammation: 35.0 %
        No significant differences in clinical, microbiological and immunological parameters between groups
  1. aPDT antimicrobial photodynamic therapy, BL baseline, BOP bleeding on probing, CHX chlorhexidine digluconate, OHI oral hygiene instructions, PD probing pocket depth, RCT randomized controlled clinical study