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Table 5 Included studies—nonsurgical treatment of peri-implant mucositis: adjunctive antibiotic therapy

From: Efficacy of alternative or adjunctive measures to conventional treatment of peri-implant mucositis and peri-implantitis: a systematic review and meta-analysis

Publication Design Population Case definition Period Test Control Mean (SD) outcome
Schenk et al. [16] RCT Split-mouth design 8 patients PD >4 mm BOP on at least 1 site per implant ± mucosal hyperplasia no radiographic bone loss 3 months Supra-/subgingival scaling (steel curettes) + polishing (rubber cup) + locally delivered tetracycline HCl (25 %) fibre for 10 days +0.2 % CHX mouthrinse twice for 10 days Supra-/subgingival scaling (steel curettes) + polishing (rubber cup) + +0.2 % CHX mouthrinse twice for 10 days ΔBOP (3 months, subject level)
   24 implants      Test: −17 ± 25 %
   1 implant type (endossous part: titanium and zirconoxide/transmucosal part: titanium oxinitride)      Control: 15 ± 37 %
        PD/CAL values without significant changes in both groups
        No adverse events
        Partial/complete fibre loss at three sites
Hallström et al. [19] RCT, parallel 45 patients PD ≥4 mm BOP + and/or pus 6 months OHI + mechanical cleansing (titanium curettes + rubber cups + polishing paste) + Azithromycin® 500 mg day 1 and 250 mg days 2–4 OHI + mechanical cleansing (titanium curettes + rubber cups + polishing paste) Test
   3 implant systems Radiographic bone loss ≤2 mm     BOP: 82.6 (24.4) (BL) to 27.3 (18.8) % (6 months, subject level)
        PD at worst site: 5.5 (0.8) (BL) to 4.1 (1.2) mm (6 months, subject level)
        Control
        BOP: 80.0 (25.0) (BL) to 47.5 (32.3) % (6 months, subject level)
        PD at worst site: 5.7 (0.8) (BL) to 4.9 (1.1) mm (6 months, subject level)
        Odds ratio of a positive treatment outcome (PD ≤ 4.0 mm and BOP ≤ 1) was 4.5:1 (test vs. control)
        Comparable reductions in bacterial counts
  1. BL baseline, BOP bleeding on probing, CAL clinical attachment level, OHI oral hygiene instructions, PD probing pocket depth, RCT randomized controlled clinical study