Publication | Design | Population | Case definition | Period | Test | Control | Mean (SD) outcome |
---|---|---|---|---|---|---|---|
RCT, parallel | 17 patients | Suppuration or sulcus bleeding, PD >4 mm horizontal peri-implant translucency | 36 months systemic antibiotic medication (Amoxicillin for 8 days) | Full mouth disinfection/mechanical debridement + resective therapy (apical re-positioned flap + bone re-contouring) + decontamination using metronidazole + tetracycline hydrochloride (3 min) + implantoplasty using diamond and arkansas burs/silicone polishers | Full mouth disinfection/mechanical debridement + resective therapy (apical re-positioned flap + bone re-contouring) + decontamination using metronidazole + tetracycline hydrochloride (3 min) | Test | |
 |  | 22 implants rough surfaces |  |  |  |  | BOP: 2.83 (0.47) (BL) to 0.5 (0.69) (24 monthsa, implant level) PD: 5.79 (1.69) (BL) to 3.58 (1.06) mm (24 monthsa, implant level) |
 |  |  |  |  |  |  | MBL: 0.0–0.01 mm (36 months, implant level) |
 |  |  |  |  |  |  | Control |
 |  |  |  |  |  |  | BOP: 2.86 (0.35) (BL) to 2.33 (0.74) (24 monthsa, implant level) |
 |  |  |  |  |  |  | PD: 6.52 (1.62) (BL) to 5.5 (1.47) mm (24 monthsa, implant level) |
 |  |  |  |  |  |  | MBL: 1.44–1.54 mm (36 months, implant level) |