Table 2 Assessment of risk of bias and heterogeneity within and across the included studies
From: Genomic analyses of early peri-implant bone healing in humans: a systematic review
Category | Ivanovski et al. [ 34 ] | Donos et al. 2011 [ 35 ] | Bryington et al. [ 36 ] | Thalji et al. [ 37 ] |
|---|---|---|---|---|
Study design | ||||
  Comparison | None (only SLActive) | SLA vs. SLActive | TiOBlast vs. Osseospeed | TiOBlast vs. Osseospeed |
  Setting | University | University | University | University |
  Population, inclusion criteria | 9 healthy volunteers with no mandibular third molars, no contraindications for oral surgery; age 21 to 48, median 29 years | 9 healthy volunteers with no mandibular third molars; age 21 to 48, median 29 years | 6 women, 4 men; implant patients, systemically healthy (no HTN, diabetes, CVD); age 25 to 58, mean 36.2 years | 9 women, 2 men; implant patients, systemically healthy; age 47 to 69, mean 60.2 years |
  Exclusion criteria | Smokers | Smokers | Smokers, pregnancy, periodontal/periapical disease, subjects taking bisphosphonates, hormone replacement therapy, corticosteroids | Smokers, uncontrolled diabetes, history of head/neck radiotherapy, taking corticosteroids, bisphosphonates |
  Comparability of groups | Unclear | Unclear | Unclear | Unclear |
  Potential confounders, e.g., post-op medication | Unclear | Unclear | Unclear | Unclear |
  Power calculation | No | No | No | No |
  Statistical correction | For multiple sampling | For multiple sampling | Unclear | For multiple sampling |
Methods | ||||
  Tissue analyzed | Peri-implant tissue | Peri-implant tissue | Implant-adherent cells | Implant-adherent cells |
  Genetic material analyzed | Total RNA | Total RNA | Total RNA | Total RNA |
  Success rate | Unclear | 16/18 samples (88.8%) | 7/10 subject samples (70%) | Unclear |
  Genotyping method | Microarray | Microarray | RT-PCR | Whole-genome microarray |
  Genotype counts | Yes | Yes | Yes | Yes |
  Blinding | Unclear | Unclear | Yes | Unclear |
  Reproducibility, validated genotyping accuracy | No | No | No | No |